Porcine cells persistently infected with classical swine fever virus protected from pestivirus-induced cytopathic effect.
نویسندگان
چکیده
منابع مشابه
Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs
Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. Efficient live attenuated vaccines against classical swine fever virus (CSFV) are used routinely in endemic countries. However, despite intensive vaccination programs in these areas for more than 20 years, CSF has not been eradicated. Molecular epidemiology studies in these regions suggests...
متن کاملSequence-based comparative study of classical swine fever virus genogroup 2.2 isolate with pestivirus reference strains
AIM This study was undertaken with the aim to compare and establish the genetic relatedness between classical swine fever virus (CSFV) genogroup 2.2 isolate and pestivirus reference strains. MATERIALS AND METHODS The available complete genome sequences of CSFV/IND/UK/LAL-290 strain and other pestivirus reference strains were retrieved from GenBank. The complete genome sequence, complete open ...
متن کاملClassical Swine Fever Virus vs. Classical Swine Fever Virus: The Superinfection Exclusion Phenomenon in Experimentally Infected Wild Boar
Two groups with three wild boars each were used: Group A (animals 1 to 3) served as the control, and Group B (animals 4 to 6) was postnatally persistently infected with the Cat01 strain of CSFV (primary virus). The animals, six weeks old and clinically healthy, were inoculated with the virulent strain Margarita (secondary virus). For exclusive detection of the Margarita strain, a specific qRT-P...
متن کاملInteraction of classical swine fever virus with dendritic cells.
Functional disruption of dendritic cells (DCs) is an important strategy for viral pathogens to evade host defences. Monocytotropic viruses such as classical swine fever virus (CSFV) could employ such a mechanism, since the virus can suppress immune responses and induce apoptosis without infecting lymphocytes. Here, CSFV was shown to infect and efficiently replicate in monocyte- and in bone marr...
متن کاملAfrican swine fever virus infection in Classical swine fever subclinically infected wild boars
BACKGROUND Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infectio...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1998
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-79-12-2981